Incidence and risk factors of retinopathy of prematurity in neonatal intensive care units: Mansoura, Egypt

Abstract

Background Retinopathy of prematurity ROP is a leading cause of blindness affecting ∼50 000 children worldwide. The incidence of the disease varies among different countries, it is influenced by the level of perinatal care, the existence of screening programs for early diagnosis. Low birth weight BW, small gestational age GA, other antenatal, postnatal risk factors have been identified with their relation to the severity of the disease. Aim The aim of this research was to study the incidence and risk factors of ROP in preterm babies at neonatal intensive care units, Mansoura city. Patients and methods This study included 402 preterm infants admitted to neonatal intensive care units in Mansoura city in the period from March 2013 to March 2015. Fundus examination was done using indirect ophthalmoscopy and a 28 D lens, and fundus images were captured using wide-field digital fundus camera (Retcam 3). Results Out of the 402 screened preterm babies, 237 (59%) cases had ROP, among whom 101 (42.6%) had stage 1, 114 (48.1%) had stage 2, 12 (5.1%) had stage 3, 10 (4.2%) had aggressive posterior retinopathy, and 24 (10.1%) presented with plus disease. GA, BW, oxygen therapy, sepsis, multiple birth, and cesarean section were factors found to be significantly associated with the disease. Conclusion ROP occurred in 59% of all screened preterm babies. The main risk factors for the development of ROP were GA, BW, oxygen therapy, sepsis, multiple birth, and cesarean section.

Keywords

• birth weight
• gestational age
• oxygen
• preterm
• retinopathy of prematurity