Tumour Cell Heterogeneity [version 1; referees: 5 approved]

Laura Gay; Ann-Marie Baker; Trevor A. Graham

doi:10.12688/f1000research.7210.1

F1000Research (Feb 2016)

Tumour Cell Heterogeneity [version 1; referees: 5 approved]

Laura Gay,
Ann-Marie Baker,
Trevor A. Graham

Affiliations

Laura Gay: Evolution and Cancer Laboratory, Centre for Tumour Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
Ann-Marie Baker: Evolution and Cancer Laboratory, Centre for Tumour Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
Trevor A. Graham: Evolution and Cancer Laboratory, Centre for Tumour Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK

DOI: https://doi.org/10.12688/f1000research.7210.1
Journal volume & issue: Vol. 5

Abstract

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The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and maintaining ITH, and discuss the ramifications and opportunities that ITH presents for cancer prognostication and treatment.

Published in F1000Research

ISSN: 2046-1402 (Online)
Publisher: F1000 Research Ltd
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://f1000research.com

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