HYPOTHYROIDISM DRUG CORRECTION INFLUENCE ON TESTICLE STRUCTURE AFTER THYROIDECTOMY

Abstract

The question of finding effective approaches to the medical correction of hypothyroidism and their morphofunctional justification continues to be one of the current issues of modern medical science. The aim of the study – to give a comparative morphofunctional characteristic of the effectiveness of monotherapy with L-thyroxin and its combination with thiotriazoline for the correction of post-thyroidectomy hypothyroidism. Materials and Methods. Experiments were carried out on mature white laboratory male rats. The mass of testicles has been established, with father observational microscopy studied of the morphological features of their structure, determined the number of convoluted seminal canals in one field of vision and the following morphometric parameters: the thickness of the protein shell, the thickness of the spermatogenic epithelium. The functional activity of the testicles was carried out by deducting the index of spermatogenesis, functional state of the vessels was carried out according to the the Wagovert index value. Results and Discussion. After thyroidectomy in the gonads of male rats, significant organ-related circulatory disorders were detected, which in the early stages were manifested by pronounced venous and moderate arterial hypertension with the simultaneous development of interstitial edema. Subsequently, the arteries of the organ reacted with a decrease of their throughput due to the narrowing of the lumen of small arteries and arterioles, which caused dystrophic changes in both the stroma and parenchyma of the organ. Trophic disorders were accompanied by the desertification of seminal tubules as a result of a quick decrease in spermatogenic epithelium cells quantity, their fibrous transformation and subsequent growth of the connective tissue in the interstitial one. The revealed structural changes are a consequence of both the direct influence of hypothyroidism on the state of their structural components, and indirectly due to violation of the organ blood flow. The use of monotherapy with L-thyroxine in the postoperative period only partly prevents the development of detected morphofunctional changes. Conclusions. More effective is the combined use of L-thyroxin with thiotriazolinum.

Keywords

• гіпотиреоз
• сперматогенез
• кровообіг
• дистрофія.