Nature Communications (Jan 2020)

Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes

  • Idit Goldfracht,
  • Stephanie Protze,
  • Assad Shiti,
  • Noga Setter,
  • Amit Gruber,
  • Naim Shaheen,
  • Yulia Nartiss,
  • Gordon Keller,
  • Lior Gepstein

DOI
https://doi.org/10.1038/s41467-019-13868-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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The cellular composition of previous engineered heart tissue is often heterogeneous. Here, the authors create chamber-specific human pluripotent stem cell-derived cardiomyocytes to form both ventricular and atrial cells before embedding in collagen-based matrix to form ring-shaped engineered heart tissue.