OncoTargets and Therapy (Dec 2020)
The Role of Exosomes in the Female Reproductive System and Breast Cancers
Abstract
Yuqi Bai,1 Jie Guo,1 Zhongshan Liu,1 Yunfeng Li,1 Shunzi Jin,2 Tiejun Wang1 1Department of Radiation Oncology, The Second Hospital of Jilin University, Changchun, People’s Republic of China; 2NHC Key Laboratory of Radiobiology, Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Tiejun WangDepartment of Radiation Oncology, The Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130022, People’s Republic of ChinaTel +86 19904449098Email [email protected]: Exosomes are nanoscale extracellular vesicles released by nearly all cell types. Exosomes were originally considered as waste receptacles for discarding unwanted cellular products; however, these organelles are now considered to be important for cell communication by delivering biologically active molecules such as proteins, DNA, non-coding RNA and mRNA. Studies have revealed that exosomes are closely related to several diseases, especially cancers. Exosomes are indispensable for the emergence and progression of tumor. Here, we review the status of research on exosomes in the female reproductive system cancers and breast cancer, focusing on their biological roles in chemical resistance and immune responses, as well as their underlying applications in drug delivery and nanotherapy and as biological markers for tumor diagnosis.Keywords: exosome, microRNA, cancer, biomarker, nanotherapy
