Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis

Jung-Hwan Kim; Tsutomu Matsubara; Jaekwon Lee; Cristina Fenollar-Ferrer; Kyungreem Han; Donghwan Kim; Shang Jia; Christopher J. Chang; Heejung Yang; Tomokazu Nagano; Kristopher W. Krausz; Sun-Hee Yim; Frank J. Gonzalez

doi:10.1038/s41467-020-20461-0

Nature Communications (Jan 2021)

Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis

Jung-Hwan Kim,
Tsutomu Matsubara,
Jaekwon Lee,
Cristina Fenollar-Ferrer,
Kyungreem Han,
Donghwan Kim,
Shang Jia,
Christopher J. Chang,
Heejung Yang,
Tomokazu Nagano,
Kristopher W. Krausz,
Sun-Hee Yim,
Frank J. Gonzalez

Affiliations

Jung-Hwan Kim: Department of Pharmacology, School of Medicine, Institute of Health Sciences, Department of Convergence Medical Science, Gyeongsang National University
Tsutomu Matsubara: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Jaekwon Lee: Department of Biochemistry, University of Nebraska-Lincoln
Cristina Fenollar-Ferrer: Laboratory of Molecular & Cellular Neurobiology, National Institute of Mental Health, National Institutes of Health
Kyungreem Han: Laboratory of Computational Biology, National Heart, Lung and Blood Institute, National Institutes of Health
Donghwan Kim: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Shang Jia: Departments of Chemistry and Molecular and Cell Biology, University of California
Christopher J. Chang: Departments of Chemistry and Molecular and Cell Biology, University of California
Heejung Yang: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Tomokazu Nagano: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Kristopher W. Krausz: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Sun-Hee Yim: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Frank J. Gonzalez: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health

DOI: https://doi.org/10.1038/s41467-020-20461-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effects on mitochondrial function.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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