Infection-resistant MRI-visible scaffolds for tissue engineering applications
Morteza Mahmoudi,
Mingming Zhao,
Yuka Matsuura,
Sophie Laurent,
Phillip C. Yang,
Daniel Bernstein,
Pilar Ruiz-Lozano,
Vahid Serpooshan
Affiliations
Morteza Mahmoudi
Stanford Cardiovascular Institute, Stanford, CA 94305, USA
Mingming Zhao
Department of Pediatrics, Stanford University, 300 Pasteur Dr., Stanford, CA 94305, USA
Yuka Matsuura
Division of Cardiovascular Medicine, Stanford University, 300 Pasteur Dr., Stanford, CA 94305, USA
Sophie Laurent
Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau, 19, B-7000 Mons, Belgium
Phillip C. Yang
Stanford Cardiovascular Institute, Stanford, CA 94305, USA
Daniel Bernstein
Stanford Cardiovascular Institute, Stanford, CA 94305, USA
Pilar Ruiz-Lozano
Stanford Cardiovascular Institute, Stanford, CA 94305, USA
Vahid Serpooshan
Stanford Cardiovascular Institute, Stanford, CA 94305, USA
Tissue engineering utilizes porous scaffolds as template to guide the new tissue growth. Clinical application of scaffolding biomaterials is hindered by implant-associated infection and impaired in vivo visibility of construct in biomedical imaging modalities. We recently demonstrated the use of a bioengineered type I collagen patch to repair damaged myocardium.By incorporating superparamagnetic iron oxide nanoparticles into this patch, here, we developed an MRI-visible scaffold. Moreover, the embedded nanoparticles impeded the growth of Salmonella bacteria in the patch. Conferring anti-infection and MRI-visible activities to the engineered scaffolds can improve their clinical outcomes and reduce the morbidity/mortality of biomaterial-based regenerative therapies.
