Comparison of histopathologic and clinical characteristics of microsatellite instability in colorectal adenocarcinomas and its impact on survival

Abstract

AbstractColorectal cancer is one of the most common cancers and a frequent cause of mortality and morbidity. In this study, we aimed to investigate the Mismatch Repair (MMR) gene products of colorectal adenocarcinomas by immunohistochemistry, to investigate the relationship between deficiency in MMR and clinicopathologic, histomorphologic, and molecular features, and to elucidate the carcinogenesis of colorectal carcinomas in our region. Our study included 224 cases diagnosed with colorectal carcinoma; at Dicle University, Faculty of Medicine, Department of Pathology, between 2008 and 2022. Primary antibodies MLH1, MSH2, MSH6, and PMS2 were used in the immunohistochemical study. In our study, a significant relationship was found between deficiency in MMR and tumour location, tumour size, distant metastasis, stromal ratio, and desmoplasia. As a result, we found that deficiency in MMR is generally associated with good prognostic features, but this may not be the case in all cases and may be influenced by some geographical characteristics.

Keywords

• MLH1
• MSH2
• MSH6
• PMS2
• microsatellite instability