Synthesis, characterization, and biological studies of some biometal complexes

Abstract

Abstract Background Metal complexes Cu[C13H8O4N]2 2, Ni[Cl3H8O4N]2 3, and Co[C13H8O4N]2 4 of bioinorganic relevance have been synthesized with the Schiff base ligand 2-furylglyoxal–anthranilic acid (FGAA) [C13H9O4N] 1. All the complexes are well characterized by various spectral and physical methods. The antimicrobial activity of the complexes has been studied against some of the pathogenic bacteria and fungi. Results Results indicate that complexes have higher antimicrobial activity than the free ligand. This would suggest that chelation reduces considerably the polarity of the metal ions in the complexes which in turn increases the hydrophobic character of the chelate and thus enables permeation, through the lipid layer of microorganisms. All the complexes were assessed for their anticancer studies against a panel of selected cancer cells HOP62 and BT474 respectively. Results showed that the complexes are promising chemotherapeutic alternatives in the search of anticancer agents. The fluorescence quenching phenomenon is observed in the Schiff base metal complexes. Conclusion The octahedral transition metal complexes 2, 3, and 4 have been obtained by treatment of ligand 2-furylglyoxal-anthranilic acid (FGAA) 1 with metal acetate. Complexes under investigations have shown antimicrobial, potential anticancer, and the DNA binding studies. Graphical abstract

Keywords

• Metal complexes
• Characterization
• Antimicrobial
• Anticancer activity
• DNA binding