Журнал инфектологии (Sep 2014)

Genetic polymorphism of immunogenic signaling system

  • V. N. Tzygan,
  • A. M. Ivanov,
  • T. A. Kamilova,
  • E. A. Коjuhova,
  • N. N. Мurashkin,
  • N. V. Tsygan

DOI
https://doi.org/10.22625/2072-6732-2011-3-2-21-27
Journal volume & issue
Vol. 3, no. 2
pp. 21 – 27

Abstract

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The functional studies underline the importance of maintaining structural integrity of the innate immune components of intracellular signaling. The molecular structures for a number of proteins and protein domains in immune signaling have been determined. These structures have assisted us in understanding innate immunity at the molecular level. A polymorphisms modulating innate immunity signal transduction has recently been shown to influence human susceptibility to many different infections, providing one more indication of the potential of host genetics to reveal physiological pathways and mechanisms that influence resistance to infectious diseases. This lection describes recently determined structures involved in TLR signaling.

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