Alantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer

Yuan Cai; Kewa Gao; Bi Peng; Zhijie Xu; Zhijie Xu; Zhijie Xu; Jinwu Peng; Jinwu Peng; Juanni Li; Xi Chen; Xi Chen; Shuangshuang Zeng; Shuangshuang Zeng; Kuan Hu; Yuanliang Yan

doi:10.3389/fphar.2021.781033

Frontiers in Pharmacology (Nov 2021)

Alantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer

Yuan Cai,
Kewa Gao,
Bi Peng,
Zhijie Xu,
Zhijie Xu,
Zhijie Xu,
Jinwu Peng,
Jinwu Peng,
Juanni Li,
Xi Chen,
Xi Chen,
Shuangshuang Zeng,
Shuangshuang Zeng,
Kuan Hu,
Yuanliang Yan

Affiliations

Yuan Cai: Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
Kewa Gao: Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
Bi Peng: Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
Zhijie Xu: Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
Zhijie Xu: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Zhijie Xu: Department of Pathology, Xiangya Changde Hospital, Changde, China
Jinwu Peng: Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
Jinwu Peng: Department of Pathology, Xiangya Changde Hospital, Changde, China
Juanni Li: Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
Xi Chen: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Xi Chen: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China
Shuangshuang Zeng: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Shuangshuang Zeng: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China
Kuan Hu: Department of Hepatobiliary Surgery, Xiangya Hospital, Central South University, Changsha, China
Yuanliang Yan: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fphar.2021.781033
Journal volume & issue: Vol. 12

Abstract

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Alantolactone (ALT) is a natural compound extracted from Chinese traditional medicine Inula helenium L. with therapeutic potential in the treatment of various diseases. Recently, in vitro and in vivo studies have indicated cytotoxic effects of ALT on various cancers, including liver cancer, colorectal cancer, breast cancer, etc. The inhibitory effects of ALT depend on several cancer-associated signaling pathways and abnormal regulatory factors in cancer cells. Moreover, emerging studies have reported several promising strategies to enhance the oral bioavailability of ALT, such as combining ALT with other herbs and using ALT-entrapped nanostructured carriers. In this review, studies on the anti-tumor roles of ALT are mainly summarized, and the underlying molecular mechanisms of ALT exerting anticancer effects on cells investigated in animal-based studies are also discussed.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

About the journal

Abstract

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