PLoS ONE (Mar 2010)

Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline.

  • Liliana B Menalled,
  • Monica Patry,
  • Natalie Ragland,
  • Phillip A S Lowden,
  • Jennifer Goodman,
  • Jennie Minnich,
  • Benjamin Zahasky,
  • Larry Park,
  • Janet Leeds,
  • David Howland,
  • Ethan Signer,
  • Allan J Tobin,
  • Daniela Brunner

DOI
https://doi.org/10.1371/journal.pone.0009793
Journal volume & issue
Vol. 5, no. 3
p. e9793

Abstract

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Previous studies of the effects of coenzyme Q10 and minocycline on mouse models of Huntington's disease have produced conflicting results regarding their efficacy in behavioral tests. Using our recently published best practices for husbandry and testing for mouse models of Huntington's disease, we report that neither coenzyme Q10 nor minocycline had significant beneficial effects on measures of motor function, general health (open field, rotarod, grip strength, rearing-climbing, body weight and survival) in the R6/2 mouse model. The higher doses of minocycline, on the contrary, reduced survival. We were thus unable to confirm the previously reported benefits for these two drugs, and we discuss potential reasons for these discrepancies, such as the effects of husbandry and nutrition.