Frontiers in Endocrinology (Jun 2024)

Association between triglyceride glucose index and breast cancer in 142,184 Chinese adults: findings from the REACTION study

  • Xueyan Wu,
  • Xueyan Wu,
  • Shuangyuan Wang,
  • Shuangyuan Wang,
  • Lin Lin,
  • Lin Lin,
  • Xiaojing Jia,
  • Xiaojing Jia,
  • Chunyan Hu,
  • Chunyan Hu,
  • Hongyan Qi,
  • Hongyan Qi,
  • Hong Lin,
  • Hong Lin,
  • Ruizhi Zheng,
  • Ruizhi Zheng,
  • Mian Li,
  • Mian Li,
  • Yu Xu,
  • Yu Xu,
  • Min Xu,
  • Min Xu,
  • Lulu Chen,
  • Tianshu Zeng,
  • Ruying Hu,
  • Zhen Ye,
  • Lixin Shi,
  • Qing Su,
  • Xuefeng Yu,
  • Li Yan,
  • Tiange Wang,
  • Tiange Wang,
  • Zhiyun Zhao,
  • Zhiyun Zhao,
  • Jie Zheng,
  • Jie Zheng,
  • Guijun Qin,
  • Qin Wan,
  • Gang Chen,
  • Meng Dai,
  • Meng Dai,
  • Xulei Tang,
  • Zhengnan Gao,
  • Feixia Shen,
  • Xuejiang Gu,
  • Zuojie Luo,
  • Yingfen Qin,
  • Li Chen,
  • Xinguo Hou,
  • Yanan Huo,
  • Qiang Li,
  • Guixia Wang,
  • Yinfei Zhang,
  • Chao Liu,
  • Youmin Wang,
  • Shengli Wu,
  • Tao Yang,
  • Huacong Deng,
  • Jiajun Zhao,
  • Yiming Mu,
  • Guang Ning,
  • Guang Ning,
  • Weiqing Wang,
  • Weiqing Wang,
  • Yufang Bi,
  • Yufang Bi,
  • Yuhong Chen,
  • Yuhong Chen,
  • Jieli Lu,
  • Jieli Lu

DOI
https://doi.org/10.3389/fendo.2024.1321622
Journal volume & issue
Vol. 15

Abstract

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BackgroundThe triglyceride glucose (TyG) index has been associated with an increased risk in breast cancer. However, this association remains unclear among the Chinese population. This study aimed to investigate whether the TyG index is associated with the risk of prevalent breast cancer in Chinese women.MethodsThis cross-sectional study included 142,184 women from the REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal) Study, which recruited adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012. The TyG index was calculated according to the formula: Ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). Multivariable-adjusted logistic regression models were used to evaluate odds ratios (ORs) and 95% confidence intervals (CIs) regarding the associations between the TyG index and breast cancer.ResultsMultivariable-adjusted logistic regression analysis showed that compared with the lowest quartile of the TyG index, the highest quartile of the TyG index was significantly associated with an increased risk of prevalent breast cancer, with an OR (95% CI) of 1.61 (1.19–2.17). In the stratified analysis, the association of each 1 SD increase in the TyG index with risk of prevalent breast cancer was more dominant in individuals with menarche at age 13–17, those who were postmenopausal, those with a history of breastfeeding, and those who had two to four children, with the ORs (95% CIs) of 1.35 (1.09–1.68), 1.27 (1.05–1.54), 1.26 (1.05–1.52), and 1.32 (1.08–1.62), respectively. Moreover, among those without discernible insulin resistance (homeostatic model assessment-insulin resistance [HOMA-IR] ≥2.5), hyperglycemia and dyslipidemia, each 1 SD increase in the TyG index was associated with a 1.36-fold increase in breast cancer risk, with an OR (95% CI) of 2.36 (1.44–3.87).ConclusionThe TyG index is significantly associated with the prevalent breast cancer risk among middle-aged and elderly Chinese women.

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