Nature Communications (Aug 2021)

Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations

  • Martin Stražar,
  • Godfrey S. Temba,
  • Hera Vlamakis,
  • Vesla I. Kullaya,
  • Furaha Lyamuya,
  • Blandina T. Mmbaga,
  • Leo A. B. Joosten,
  • Andre J. A. M. van der Ven,
  • Mihai G. Netea,
  • Quirijn de Mast,
  • Ramnik J. Xavier

DOI
https://doi.org/10.1038/s41467-021-25213-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

Read online

The authors profile stool metagenomics and plasma metabolomics in Tanzanian individuals and uncover a gradient of gut microbial profiles, from rural through urban Tanzania towards Western populations. Integration with ex vivo blood microbial stimulations reveals immune responses associated with histidine and arginine pathways, mediated by Bifidobacterium longum and Akkermansia muciniphila.