Salmonella enterica serovar Typhi osteomyelitis in a young adult with sickle cell and thalassemia traits: A possible association
Stephanie Stephanie,
Sarah A. Schmalzle
Affiliations
Stephanie Stephanie
University of Maryland Medical Center Midtown Campus, 827 Linden Avenue, Baltimore, MD, 21201, United States
Sarah A. Schmalzle
University of Maryland Medical Center Midtown Campus, 827 Linden Avenue, Baltimore, MD, 21201, United States; Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD, 21201, United States; Division of Infectious Diseases, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD, 21201, United States; Corresponding author at: Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD, 21201, United States.
Salmonella osteomyelitis is known to occur in immunocompromised and sickle cell disease patients. It rarely occurs in other hosts. We present a case of chronic femoral osteomyelitis due to S. enterica serovar Typhi seen in a Maryland resident. Potential risk factors included traveling to an endemic area as well as a newly diagnosed sickle cell trait and thalassemia trait. It is postulated that less severe hemoglobinopathies may also contribute to an elevated risk of Salmonella osteomyelitis. Keywords: Salmonella, Typhoid fever, Osteomyelitis, Sickle cell, Thalassemia, Hemoglobinopathy
