GIGANTEA recruits the UBP12 and UBP13 deubiquitylases to regulate accumulation of the ZTL photoreceptor complex

Chin-Mei Lee; Man-Wah Li; Ann Feke; Wei Liu; Adam M. Saffer; Joshua M. Gendron

doi:10.1038/s41467-019-11769-7

Nature Communications (Aug 2019)

GIGANTEA recruits the UBP12 and UBP13 deubiquitylases to regulate accumulation of the ZTL photoreceptor complex

Chin-Mei Lee,
Man-Wah Li,
Ann Feke,
Wei Liu,
Adam M. Saffer,
Joshua M. Gendron

Affiliations

Chin-Mei Lee: Department of Molecular, Cellular, and Developmental Biology, Yale University
Man-Wah Li: Department of Molecular, Cellular, and Developmental Biology, Yale University
Ann Feke: Department of Molecular, Cellular, and Developmental Biology, Yale University
Wei Liu: Department of Molecular, Cellular, and Developmental Biology, Yale University
Adam M. Saffer: Department of Molecular, Cellular, and Developmental Biology, Yale University
Joshua M. Gendron: Department of Molecular, Cellular, and Developmental Biology, Yale University

DOI: https://doi.org/10.1038/s41467-019-11769-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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The daily accumulation of the ZEITLUPE (ZTL) photoreceptor/E3 ubiquitin ligase relies on a light-dependent interaction with GIGANTEA (GI). Here the authors show that GI recruits two deubiquitylases to help stabilize the ZTL-GI complex during the day and likely counterbalance the activity of ZTL.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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