Evaluation and chemical profiling of different Centaurea iberica extracts and investigation of different in vitro biological activities

Abstract

In almost all cultures medicinal plants are used as a rich source of phytochemicals and nutraceuticals components and have played promising role in maintaining and improving human health. The current study was aimed to unveil biological evaluation of Centaurea iberica. Plant extracts were prepared in five different solvents viz. methanol, ethanol, n-hexane, ethyl acetate and chloroform. The antioxidant potentials (2,2-diphenyl, 1-picrylhydrazine scavenging activity, total reducing power) of the plant revealed that the methanolic extract showed significant DPPH (2,2-diphenyl, 1-picrylhydrazine) scavenging activity (IC50 value 77.20 ± 8.81), reducing power (20.45 ± 0.54 AAE mg/g). In case of antibacterial assay, highest zone of inhibition (20 ± 1.5 mm) was recorded in methanolic extract against Klebsiella pneumonia. Likewise, for antifungal activity the highest zone of inhibition was recorded for methanolic extract (18 ± 2.4 mm) against Aspergillus niger. Moreover, 50 % inhibition was observed for methanolic extract against targated PC3 (prostate cancer cell line) cell lines and 3T3 cell lines. In the light of present study, it is recommended that further in vitro and in vivo studies should be performed using different animal models and characterization should be done to isolate different compounds that could be used to treat different types of ailments.

Keywords

• Antibacterial
• Antifungal
• Anticancer
• Antioxidant
• Centaurea iberica