Multi-triazole-resistant Aspergillus fumigatus and SARS-CoV-2 co-infection: A lethal combination

Aia Mohamed; Tidi Hassan; Marta Trzos-Grzybowska; Jubil Thomas; Aidan Quinn; Maire O'Sullivan; Auveen Griffin; Thomas R. Rogers; Alida Fe Talento

Medical Mycology Case Reports (Mar 2021)

Multi-triazole-resistant Aspergillus fumigatus and SARS-CoV-2 co-infection: A lethal combination

Aia Mohamed,
Tidi Hassan,
Marta Trzos-Grzybowska,
Jubil Thomas,
Aidan Quinn,
Maire O'Sullivan,
Auveen Griffin,
Thomas R. Rogers,
Alida Fe Talento

Affiliations

Aia Mohamed: Department of Microbiology, Our Lady of Lourdes Hospital Drogheda, Co. Louth, Ireland
Tidi Hassan: Department of Medicine, Our Lady of Lourdes Hospital Drogheda, Co. Louth, Ireland
Marta Trzos-Grzybowska: Department of Microbiology, Our Lady of Lourdes Hospital Drogheda, Co. Louth, Ireland
Jubil Thomas: Department of Anaesthesia and Intensive Care, Our Lady of Lourdes Hospital Drogheda, Co. Louth, Ireland
Aidan Quinn: Department of Radiology, Our Lady of Lourdes Hospital Drogheda, Co. Louth, Ireland
Maire O'Sullivan: Department of Microbiology, St. James's Hospital, Dublin, Ireland; Deparment of Clinical Microbiology, Trinity College Dublin, Dublin, Ireland
Auveen Griffin: Department of Microbiology, St. James's Hospital, Dublin, Ireland
Thomas R. Rogers: Department of Microbiology, St. James's Hospital, Dublin, Ireland; Deparment of Clinical Microbiology, Trinity College Dublin, Dublin, Ireland
Alida Fe Talento: Department of Microbiology, Our Lady of Lourdes Hospital Drogheda, Co. Louth, Ireland; Department of Microbiology, Royal College of Surgeons, Ireland, Dublin, Ireland; Corresponding author. Department of Microbiology, Our Lady of Lourdes Hospital Drogheda, Co. Louth, Ireland.

Journal volume & issue: Vol. 31
pp. 11 – 14

Abstract

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We report a case of severe COVID-19 pneumonia complicated by fatal co-infection with a multi-triazole resistant Aspergillus fumigatus and highlight the importance of recognising the significance of Aspergillus sp. isolation from respiratory samples. Early diagnosis and detection of triazole resistance are essential for appropriate antifungal therapy to improve outcome in patients with coronavirus associated invasive aspergillosis.

Published in Medical Mycology Case Reports

ISSN: 2211-7539 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: https://www.journals.elsevier.com/medical-mycology-case-reports/

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