Nature Communications (Apr 2019)
Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction
- Feng Gao,
- Masaharu Kataoka,
- Ning Liu,
- Tian Liang,
- Zhan-Peng Huang,
- Fei Gu,
- Jian Ding,
- Jianming Liu,
- Feng Zhang,
- Qing Ma,
- Yingchao Wang,
- Mingming Zhang,
- Xiaoyun Hu,
- Jan Kyselovic,
- Xinyang Hu,
- William T. Pu,
- Jian’an Wang,
- Jinghai Chen,
- Da-Zhi Wang
Affiliations
- Feng Gao
- Department of Cardiology, The Second Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine
- Masaharu Kataoka
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Ning Liu
- Department of Cardiology, The Second Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine
- Tian Liang
- Department of Cardiology, The Second Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine
- Zhan-Peng Huang
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Fei Gu
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Jian Ding
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Jianming Liu
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Feng Zhang
- Department of Cardiology, The Second Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine
- Qing Ma
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Yingchao Wang
- Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine
- Mingming Zhang
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Xiaoyun Hu
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Jan Kyselovic
- Faculty of Pharmacy, Comenius University
- Xinyang Hu
- Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine
- William T. Pu
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Jian’an Wang
- Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine
- Jinghai Chen
- Department of Cardiology, The Second Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine
- Da-Zhi Wang
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-019-09530-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
The miR-17-92 cluster has been shown to regulate cardiomyocyte proliferation in vitro and in genetic mutation and overexpression models. Here the authors show that the cluster member miR-19a/19b regulates cardiomyocyte proliferation in vivo, and that delivery of miR-19a/19b to the heart leads to both short-term and long-term protective responses to myocardial infarction.
