Antibiotics (Feb 2024)

3Y-TZP/Ta Biocermet as a Dental Material: An Analysis of the In Vitro Adherence of Streptococcus Oralis Biofilm and an In Vivo Pilot Study in Dogs

  • Anton Smirnov,
  • Oleg Yanushevich,
  • Natella Krikheli,
  • Nestor Washington Solis Pinargote,
  • Pavel Peretyagin,
  • Sergey Grigoriev,
  • Luis Alou,
  • David Sevillano,
  • Roberto López-Piriz,
  • Francisco Guitian,
  • José Florindo Bartolomé

DOI
https://doi.org/10.3390/antibiotics13020175
Journal volume & issue
Vol. 13, no. 2
p. 175

Abstract

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The surface adhesion of bacterial cells and the in vivo biocompatibility of a new ceramic–metal composite made of zirconium dioxide and tantalum were evaluated. Within the framework of an in vitro study using the crystal violet staining and colony counting methods, a relatively similar adhesion of Streptococcus oralis to the 3Y-TZP/Ta biocermet (roughness Ra = 0.12 ± 0.04 µm) and Ti-Al6-V4 titanium alloy (Ra = 0.04 ± 0.01 µm) was found. In addition, in an in vivo preliminary study focused on the histological analysis of a series of rods implanted in the jaws of beagle dogs for a six-month period, the absence of any fibrous tissue or inflammatory reaction at the interface between the implanted 3Y-TZP/Ta biocermets and the new bone was found. Thus, it can be concluded that the developed ceramic–metal biocomposite may be a promising new material for use in dentistry.

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