Three-Year Clinical Follow-Up of Children Intrauterine Exposed to Zika Virus
Rosa Estela Gazeta,
Ana Paula Antunes Pascalicchio Bertozzi,
Rita de Cássia de Aguirre Bernardes Dezena,
Andrea Cristina Botelho Silva,
Thamirys Cosmo Gillo Fajardo,
Daniel T. Catalan,
Maria de Fátima Valente Rizzo,
Antonio Fernandes Moron,
Antoni Soriano-Arandes,
Nuria Sanchez Clemente,
Tania Quintella,
Dora Fix Ventura,
Francisco Max Damico,
Valtenice de Cassia Rodrigues de Matos França,
Juliana Paula Gomes de Almeida,
Ana Laura de Sene Amâncio Zara,
Lucas Castro Pires,
Cohort Zika vírus Jundiaí,
Saulo Duarte Passos
Affiliations
Rosa Estela Gazeta
Pediatrics Department, Jundiaí Medical School, Jundiaí 13202-550, Brazil
Ana Paula Antunes Pascalicchio Bertozzi
Pediatrics Department, Jundiaí Medical School, Jundiaí 13202-550, Brazil
Rita de Cássia de Aguirre Bernardes Dezena
University Center Campo Limpo Paulista-UNIFACCAMP, Campo Limpo Paulista, São Paulo 13231-230, Brazil
Andrea Cristina Botelho Silva
Pediatric Infectology Laboratory, Jundiaí Medical School, Jundiaí 13202-550, Brazil
Thamirys Cosmo Gillo Fajardo
Pediatric Infectology Laboratory, Jundiaí Medical School, Jundiaí 13202-550, Brazil
Daniel T. Catalan
Pediatric Infectology Laboratory, Jundiaí Medical School, Jundiaí 13202-550, Brazil
Maria de Fátima Valente Rizzo
Pediatrics Department, Jundiaí Medical School, Jundiaí 13202-550, Brazil
Antonio Fernandes Moron
Tropical Medicine Institute, Campus São Paulo, University of São Paulo (USP), São Paulo 05403-000, Brazil
Antoni Soriano-Arandes
Paediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron, Vall d’Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
Nuria Sanchez Clemente
Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Tania Quintella
Pediatric Emergency Department, Pediatrics Department -Pontifícia Universidade Católica de Campinas, Campinas 13086900, Brazil
Dora Fix Ventura
Department of Experimental Psychology, Institute of Psychology, Campus São Paulo, University of São Paulo, São Paulo 05588-030, Brazil
Francisco Max Damico
Department of Experimental Psychology, Institute of Psychology, Campus São Paulo, University of São Paulo, São Paulo 05588-030, Brazil
Valtenice de Cassia Rodrigues de Matos França
Department of Experimental Psychology, Institute of Psychology, Campus São Paulo, University of São Paulo, São Paulo 05588-030, Brazil
Juliana Paula Gomes de Almeida
Pediatric Neurology Department, School of Medical Sciences of Santa Casa de São Paulo, São Paulo 01221-010, Brazil
Ana Laura de Sene Amâncio Zara
Department of Collective Health, Tropical InstitutePathology and Public Health, Federal University of Goiás, Goiânia 74690-000, Brazil
Lucas Castro Pires
Faculty of Medicine, Jundiaí Medical School, Jundiaí 13202-550, Brazil
Cohort Zika vírus Jundiaí
Cohort Zika vírus Jundiaí, Jundiaí 13207-450, Brazil
Saulo Duarte Passos
Pediatrics Department, Jundiaí Medical School, Jundiaí 13202-550, Brazil
Congenital Zika virus (ZIKV) infection may present with a broad spectrum of clinical manifestations. Some sequelae, particularly neurodevelopmental problems, may have a later onset. We conducted a prospective cohort study of 799 high-risk pregnant women who were followed up until delivery. Eighty-three women and/or newborns were considered ZIKV exposed and/or infected. Laboratory diagnosis was made by polymerase chain reaction in the pregnant mothers and their respective newborns, as well as Dengue virus, Chikungunya virus, and ZIKV serology. Serology for toxoplasmosis, rubella, cytomegalovirus, herpes simplex virus, and syphilis infections were also performed in microcephalic newborns. The newborns included in the study were followed up until their third birthday. Developmental delay was observed in nine patients (13.2%): mild cognitive delay in three patients, speech delay in three patients, autism spectrum disorder in two patients, and severe neurological abnormalities in one microcephalic patient; sensorineural hearing loss, three patients and dysphagia, six patients. Microcephaly due to ZIKV occurred in three patients (3.6%). Clinical manifestations can appear after the first year of life in children infected/exposed to ZIKV, emphasizing the need for long-term follow-up.