Ferritin as a marker of Insulin Resistance in Diabetic Patients

Abstract

Backgroud : Insulin resistance is a pathogenic hallmark of type 2 diabetes mellitus (T2DM).Serum ferritin, a predominant iron-storage protein and a biomarker of iron stores, are elevated in persons with prevalent diabetes as compared with non-diabetic controls and correlate with impaired fasting glucose levels.High ferritin levels have been associated with the metabolic syndrome and measures of insulin resistance .The aim of the current study : is to measure Serum Ferritin in patients with type 2 diabetes in Beni- Suef governorate and to study the relationship between serum Ferritin and Insulin Resistance. Patients and Methods : This study involved 40 patients with type 2 diabetes (24 females and 16 males) and 20 healthy adults (12 females and 8 males) served as a control group. All groups included in this study were subjected to Full History Taking, Clinical Examination including (BMI & Waist Circ.) and Laboratory Investigation including ( FPG, HbA1c, Serum Ferritin and Fasting Serum Insulin & measuring HOMA-IR).Results : Ferritin showed a statistically significant correlation with Waist Circ., FPG, HbA1c, Fasting Serum Insulin and Insulin Resistance (HOMA-IR) in the diabetic group (P < 0.05) .Conclusion: Serum ferritin can be used as a marker of insulin resistance syndrome in diabetics

Keywords

• ferritin
• insulin resistance
• type 2 diabetes