Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes

Joseph Kwasi Adu; Cedric Dzidzor Kodjo Amengor; Nurudeen Mohammed Ibrahim; Cynthia Amaning-Danquah; Charles Owusu Ansah; Dorcas Dzifa Gbadago; Joseph Sarpong-Agyapong

doi:10.1155/2020/4850492

Journal of Tropical Medicine (Jan 2020)

Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes

Joseph Kwasi Adu,
Cedric Dzidzor Kodjo Amengor,
Nurudeen Mohammed Ibrahim,
Cynthia Amaning-Danquah,
Charles Owusu Ansah,
Dorcas Dzifa Gbadago,
Joseph Sarpong-Agyapong

Affiliations

Joseph Kwasi Adu: Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana
Cedric Dzidzor Kodjo Amengor: Department of Pharmaceutical Chemistry, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana
Nurudeen Mohammed Ibrahim: Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana
Cynthia Amaning-Danquah: Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana
Charles Owusu Ansah: Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana
Dorcas Dzifa Gbadago: Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana
Joseph Sarpong-Agyapong: Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana

DOI: https://doi.org/10.1155/2020/4850492
Journal volume & issue: Vol. 2020

Abstract

Read online

The antimicrobial activity of 2-naphtholic and phenolic azo compounds was determined against seven microbial species, Staphylococcus aureus (ATCC 25923), Streptococcus pyrogenes (clinical), and Enterococcus faecalis (ATCC 29212), Salmonella typhi (clinical), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 251922), and Candida albicans (ATCC 10231), using the high-throughput spot culture growth inhibition assay (HT-SPOTi). The minimum inhibitory concentrations (MIC) were determined for the active azo dyes. All the azo compounds (A1–B4) were screened for anthelmintic activity against adult Ghanaian earthworms, Hyperiodrilus spp. As part of the systematic investigation for biological activity, all the azo compounds exhibited good antimicrobial activity against the seven human pathogenic microorganisms. All the compounds exhibited anthelminthic activity against adult Ghanaian earthworms, Hyperiodrilus spp.

Published in Journal of Tropical Medicine

ISSN: 1687-9686 (Print); 1687-9694 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Special situations and conditions: Arctic medicine. Tropical medicine
Website: https://www.hindawi.com/journals/jtm/

About the journal