Indian Journal of Ophthalmology (Jan 2013)
Cross-linking for microbial keratitis
- Jayesh Vazirani,
- Pravin K Vaddavalli
Affiliations
- Jayesh Vazirani
- Pravin K Vaddavalli
- DOI
- https://doi.org/10.4103/0301-4738.116068
- Journal volume & issue
-
Vol. 61,
no. 8
pp. 441 – 444
Abstract
The success of collagen cross-linking as a clinical modality to modify the clinical course in keratoconus seems to have fueled the search for alternative applications for this treatment. Current clinical data on its efficacy is limited and laboratory data seems to indicate that it performs poorly against resistant strains of bacteria and against slow growing organisms. However, the biological plausibility of crosslinking and the lack of effective strategies in managing infections with these organisms continue to focus attention on this potential treatment. Well-conducted experimental and clinical studies with controls are required to answer the questions of its efficacy in future.
Keywords
- Epidemiology
- keratoconus
- prevalence
- Disease pathogenesis
- genetic heterogeneity
- genetics and genomics
- genome-wide association study
- genomic loci
- keratoconus
- linkage mapping
- molecular mechanisms
- whole exome-genome sequencing
- Deregulation
- ectasia
- gene expression
- keratoconus
- mass spectroscopy
- proteomics
- signaling pathways
- Cornea
- crosslinking
- keratoconus
- modulus
- Corneal topography
- imaging
- keratoconus
- optical coherence tomography
- placido disc based topography
- Ectatic disease
- keratoconus
- scheimpflug imaging
- Keratoconus
- ocular allergy
- vernal keratoconjunctivitis
- Contact lens
- keratoconus
- piggy back contact lenses
- rigid gas permeable
- scleral lens
- SynergEyes
- toric soft contact lens
- Corneal cross-linking techniques
- new technologies
- riboflavin
- Collagen cross linking
- Corneal collagen cross-linking
- hypoosmolar riboflavin
- keratoconus
- thin cornea
- transepithelial collagen cross-linking
- Corneal cross-linking
- radiant exposure
- ultraviolet-A
- Accelerated corneal cross linking
- keratoconus
- corneal laser surgery
- corneal ectasia
- UV light
- riboflavin
- Laser in situ keratomileusis surgery
- very high fluence collagen cross-linking
- corneal ectosia
- LASIK ectosia prophylaxis
- Cornea collagen cross linking
- keratoconus
- long term results
- Corneal collagen cross linking
- corneal transplant
- keratoconus
- pediatric keratoconus
- Collagen cross-linking
- microbial keratitis
- riboflavin
- fungus
- acanth