Cholecystokinin-like peptide (DSK) in Drosophila, not only for satiety signaling

Abstract

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Cholecystokinin (CCK) signaling appears well conserved over evolution. In Drosophila the CCK-like sulfakinins (DSKs) regulate aspects of gut function, satiety and food ingestion, hyperactivity and aggression, as well as escape-related locomotion and synaptic plasticity during NMJ development. Activity in the DSK-producing neurons is regulated by octopamine. We discuss mechanisms behind CCK function in satiety, aggression and locomotion in some detail and highlight similarities to mammalian CCK signaling.

Keywords

• Aggression
• Locomotion
• feeding
• Neuropeptide
• peptide hormone
• Intestinal function