Frontiers in Pediatrics (Jul 2021)
Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown
- Marie Isabel Rasmussen,
- Mathias Lühr Hansen,
- Gerhard Pichler,
- Eugene Dempsey,
- Adelina Pellicer,
- Afif EL-Khuffash,
- Shashidhar A,
- Salvador Piris-Borregas,
- Miguel Alsina,
- Merih Cetinkaya,
- Lina Chalak,
- Hilal Özkan,
- Mariana Baserga,
- Jan Sirc,
- Hans Fuchs,
- Ebru Ergenekon,
- Luis Arruza,
- Amit Mathur,
- Martin Stocker,
- Olalla Otero Vaccarello,
- Tomasz Szczapa,
- Kosmas Sarafidis,
- Barbara Królak-Olejnik,
- Asli Memisoglu,
- Hallvard Reigstad,
- Elżbieta Rafińska-Ważny,
- Eleftheria Hatzidaki,
- Zhang Peng,
- Despoina Gkentzi,
- Renaud Viellevoye,
- Julie De Buyst,
- Emmanuele Mastretta,
- Ping Wang,
- Gitte Holst Hahn,
- Lars Bender,
- Luc Cornette,
- Jakub Tkaczyk,
- Ruth del Rio,
- Monica Fumagalli,
- Monica Fumagalli,
- Evangelia Papathoma,
- Maria Wilinska,
- Gunnar Naulaers,
- Iwona Sadowska-Krawczenko,
- Chantal Lecart,
- María Luz Couce,
- Siv Fredly,
- Anne Marie Heuchan,
- Tanja Karen,
- Gorm Greisen
Affiliations
- Marie Isabel Rasmussen
- Department of Neonatology, Rigshospitalet, Copenhagen, Denmark
- Mathias Lühr Hansen
- Department of Neonatology, Rigshospitalet, Copenhagen, Denmark
- Gerhard Pichler
- Department of Pediatrics, Medical University of Graz, Graz, Austria
- Eugene Dempsey
- Infant Centre and Department of Paediatrics and Child Health, University College Cork, Cork, Ireland
- Adelina Pellicer
- Department of Neonatology, La Paz University Hospital, Madrid, Spain
- Afif EL-Khuffash
- Department of Pediatrics, The Royal College of Surgeons in Ireland, Dublin, Ireland
- Shashidhar A
- St. Johns Medical College Hospital, Bengaluru, India
- Salvador Piris-Borregas
- Department of Neonatology, 12 Octubre University Hospital, Madrid, Spain
- Miguel Alsina
- Neonatology Department, Hospital Clínic-Maternintat, Barcelona, Spain
- Merih Cetinkaya
- Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey
- Lina Chalak
- 0Division of Pediatrics - Neonatal-Perinatal, University of Texas (UT) Southwestern, Dallas, TX, United States
- Hilal Özkan
- 1Division of Neonatology, Department of Pediatrics, Uludag University Medical Faculty, Uludag, Turkey
- Mariana Baserga
- 2Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, United States
- Jan Sirc
- 3Third Faculty of Medicine, Institute for the Care of the Mother and Child, Charles University, Prague, Czechia
- Hans Fuchs
- 4Center for Pediatrics, Department of Neonatology, Medical Center, University of Freiburg, Freiburg, Germany
- Ebru Ergenekon
- 5Department of Neonatology, Gazi University Hospital, Ankara, Turkey
- Luis Arruza
- 6Division of Neonatology, Instituto del Niño y del Adolescente, Hospital Clinico San Carlos-Health Research Institute San Carlos (IdISSC), Madrid, Spain
- Amit Mathur
- 7Department of Neonatal-Perinatal Medicine, Saint Louis University School of Medicine, St. Louis, MO, United States
- Martin Stocker
- 8Neonatal and Pediatric Intensive Care Unit, Children's Hospital Lucerne, Lucerne, Switzerland
- Olalla Otero Vaccarello
- 9Department of Neonatology, Hospital Universitario de Tarragona Juan XXIII, Tarragona, Spain
- Tomasz Szczapa
- 0Department of Neonatology, Neonatal Biophysical Monitoring and Cardiopulmonary Therapies Research Unit, Poznan University of Medical Sciences, Poznań, Poland
- Kosmas Sarafidis
- 1First Department of Neonatology, Aristotle University, Hippokrateion General Hospital, Thessaloniki, Greece
- Barbara Królak-Olejnik
- 2Department of Neonatology, Wrocław Medical University, Wrocław, Poland
- Asli Memisoglu
- 3Department of Neonatology, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey
- Hallvard Reigstad
- 4Department of Neonatology, Haukeland University Hospital, Bergen, Norway
- Elżbieta Rafińska-Ważny
- 5Department of Neonatology, Centrum Medyczne “Ujastek”, Krakow, Poland
- Eleftheria Hatzidaki
- 6Department of Neonatology and Neonatal Intensive Care Unit (NICU), University Hospital of Heraklion, Crete, Greece
- Zhang Peng
- 7Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China
- Despoina Gkentzi
- 8Neonatal Intensive Care Unit (NICU), Department of Pediatrics, Patras Medical School, Patras, Greece
- Renaud Viellevoye
- 9Neonatal Intensive Care Unit, Department of Pediatrics, University of Liege, Liege, Belgium
- Julie De Buyst
- 0Neonatal Intensive Care Unit (NICU), Tivoli Hospital, La Louviere, Belgium
- Emmanuele Mastretta
- 1S.C. Neonatologia - Pres Osp S. Anna – Citta della Salute e della Scienza di Torino, Torino, Italy
- Ping Wang
- 2Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou, China
- Gitte Holst Hahn
- Department of Neonatology, Rigshospitalet, Copenhagen, Denmark
- Lars Bender
- 3Department of Neonatology, Aalborg University Hospital, Aalborg, Denmark
- Luc Cornette
- 4Department of Neonatology, AZ St-Jan Bruges, Bruges, Belgium
- Jakub Tkaczyk
- 5Department of Neonatology, University Hospital Motol, Prague, Czechia
- Ruth del Rio
- 6Department of Neonatology, Hospital Sant Joan de Déu, Barcelona, Spain
- Monica Fumagalli
- 7Department of Neonatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Milan, Italy
- Monica Fumagalli
- 8Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
- Evangelia Papathoma
- 9Neonatal Intensive Care Unit, “Alexandra” University and State Maternity Hospital, Athens, Greece
- Maria Wilinska
- 0Neonatology Department, Centre of Postgraduate Medical Education, Warsaw, Poland
- Gunnar Naulaers
- 1Department of Neonatology, University Hospital Leuven, Leuven, Belgium
- Iwona Sadowska-Krawczenko
- 2Department of Neonatology, Collegium Medicum in Bydgoszcz Nicolaus Copernicus University, Toruń, Poland
- Chantal Lecart
- 3Department of Neonatology, Grand Hôpital de Charleroi (GHdC), Charleroi, Belgium
- María Luz Couce
- 4Neonatology Department, University Clinical Hospital of Santiago de Compostela, Health Research Institute of Santiago de Compostela, Santiago, Spain
- Siv Fredly
- 5Department of Neonatology, Oslo University Hospital, Oslo, Norway
- Anne Marie Heuchan
- 6Department of Neonatology, Royal Hospital for Children, Glasgow, United Kingdom
- Tanja Karen
- 7Department of Neonatology, University Hospital Zurich, Zurich, Switzerland
- Gorm Greisen
- Department of Neonatology, Rigshospitalet, Copenhagen, Denmark
- DOI
- https://doi.org/10.3389/fped.2021.647880
- Journal volume & issue
-
Vol. 9
Abstract
Objective: To evaluate if the number of admitted extremely preterm (EP) infants (born before 28 weeks of gestational age) differed in the neonatal intensive care units (NICUs) of the SafeBoosC-III consortium during the global lockdown when compared to the corresponding time period in 2019.Design: This is a retrospective, observational study. Forty-six out of 79 NICUs (58%) from 17 countries participated. Principal investigators were asked to report the following information: (1) Total number of EP infant admissions to their NICU in the 3 months where the lockdown restrictions were most rigorous during the first phase of the COVID-19 pandemic, (2) Similar EP infant admissions in the corresponding 3 months of 2019, (3) the level of local restrictions during the lockdown period, and (4) the local impact of the COVID-19 lockdown on the everyday life of a pregnant woman.Results: The number of EP infant admissions during the first wave of the COVID-19 pandemic was 428 compared to 457 in the corresponding 3 months in 2019 (−6.6%, 95% CI −18.2 to +7.1%, p = 0.33). There were no statistically significant differences within individual geographic regions and no significant association between the level of lockdown restrictions and difference in the number of EP infant admissions. A post-hoc analysis based on data from the 46 NICUs found a decrease of 10.3%in the total number of NICU admissions (n = 7,499 in 2020 vs. n = 8,362 in 2019).Conclusion: This ad hoc study did not confirm previous reports of a major reduction in the number of extremely pretermbirths during the first phase of the COVID-19 pandemic.Clinical Trial Registration:ClinicalTrial.gov, identifier: NCT04527601 (registered August 26, 2020), https://clinicaltrials.gov/ct2/show/NCT04527601.
Keywords
- extremely preterm
- COVID-19
- randomized clinical trial
- pandemic
- observational study
- neonatal intensive care unit admission
