Journal of Clinical Medicine (Mar 2022)

Predictors of Positive Surgical Margins after Robot-Assisted Partial Nephrectomy for Localized Renal Tumors: Insights from a Large Multicenter International Prospective Observational Project (The Surface-Intermediate-Base Margin Score Consortium)

  • Fabrizio Di Maida,
  • Riccardo Campi,
  • Brian R. Lane,
  • Ottavio De Cobelli,
  • Francesco Sanguedolce,
  • Georgios Hatzichristodoulou,
  • Alessandro Antonelli,
  • Antonio Andrea Grosso,
  • Sabrina Noyes,
  • Oscar Rodriguez-Faba,
  • Frank X. Keeley,
  • Johan Langenhuijsen,
  • Gennaro Musi,
  • Tobias Klatte,
  • Marco Roscigno,
  • Bulent Akdogan,
  • Maria Furlan,
  • Claudio Simeone,
  • Nihat Karakoyunlu,
  • Martin Marszalek,
  • Umberto Capitanio,
  • Alessandro Volpe,
  • Sabine Brookman-May,
  • Jürgen E. Gschwend,
  • Marc C. Smaldone,
  • Robert G. Uzzo,
  • Alexander Kutikov,
  • Andrea Minervini,
  • SIB International Consortium

DOI
https://doi.org/10.3390/jcm11071765
Journal volume & issue
Vol. 11, no. 7
p. 1765

Abstract

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Background: To explore predictors of positive surgical margins (PSM) after robotic partial nephrectomy (PN) in a large multicenter international observational project, harnessing the Surface-Intermediate-Base (SIB) margin score to report the resection technique after PN in a standardized way. Methods: Data from consecutive patients with cT1-2N0M0 renal masses treated with PN from September 2014 to March 2015 at 16 tertiary referral centers and included in the SIB margin score International Consortium were prospectively collected. For the present study, only patients treated with robotic PN were included. Uni- and multivariable analysis were fitted to explore clinical and surgical predictors of PSMs after PN. Results: Overall, 289 patients were enrolled. Median (IQR) preoperative tumor size was 3.0 (2.3–4.2) cm and median (IQR) PADUA score was 8 (7–9). SIB scores of 0–2 (enucleation), 3–4 (enucleoresection) and 5 (resection) were reported in 53.3%, 27.3% and 19.4% of cases, respectively. A PSM was recorded in 18 (6.2%) patients. PSM rate was 4.5%, 11.4% and 3.6% in case of enucleation, enucleoresection and resection, respectively. Patients with PSMs had tumors with a higher rate of contact with the urinary collecting system (55.6% vs. 27.3%; p p = 0.02) compared with patients with negative surgical margins, while no differences emerged between the two groups in terms of other tumor features (i.e., pathological diameter, PADUA score). In multivariable analysis, only enucleoresection (SIB score 3–4) versus enucleation (SIB score 0–2) was found to be an independent predictor of PSM at final pathology (HR: 2.68; 95% CI: 1.25–7.63; p = 0.04), while resection (SIB score 5) was not. Conclusions: In our experience, enucleoresection led to a higher risk of PSMs as compared to enucleation. Further studies are needed to assess the differential impacts of resection technique and surgeon’s experience on margin status after robotic PN.

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