Nature Communications (Nov 2016)
Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers
- Eva Pérez-Guijarro,
- Panagiotis Karras,
- Metehan Cifdaloz,
- Raúl Martínez-Herranz,
- Estela Cañón,
- Osvaldo Graña,
- Celia Horcajada-Reales,
- Direna Alonso-Curbelo,
- Tonantzin G. Calvo,
- Gonzalo Gómez-López,
- Nicolas Bellora,
- Erica Riveiro-Falkenbach,
- Pablo L. Ortiz-Romero,
- José L. Rodríguez-Peralto,
- Lorena Maestre,
- Giovanna Roncador,
- Juan C. de Agustín Asensio,
- Colin R. Goding,
- Eduardo Eyras,
- Diego Megías,
- Raúl Méndez,
- María S. Soengas
Affiliations
- Eva Pérez-Guijarro
- Melanoma Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
- Panagiotis Karras
- Melanoma Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
- Metehan Cifdaloz
- Melanoma Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
- Raúl Martínez-Herranz
- Melanoma Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
- Estela Cañón
- Melanoma Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
- Osvaldo Graña
- Bioinformatics Unit (CNIO)
- Celia Horcajada-Reales
- Department of Dermatology, Hospital Gregorio Marañón
- Direna Alonso-Curbelo
- Melanoma Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
- Tonantzin G. Calvo
- Melanoma Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
- Gonzalo Gómez-López
- Bioinformatics Unit (CNIO)
- Nicolas Bellora
- Department of Experimental and Health Sciences, Universidad Pompeu Fabra
- Erica Riveiro-Falkenbach
- Instituto de Investigación i+12, Hospital 12 de Octubre, Medical School, Universidad Complutense
- Pablo L. Ortiz-Romero
- Instituto de Investigación i+12, Hospital 12 de Octubre, Medical School, Universidad Complutense
- José L. Rodríguez-Peralto
- Instituto de Investigación i+12, Hospital 12 de Octubre, Medical School, Universidad Complutense
- Lorena Maestre
- Monoclonal Antibodies Unit, Biotechnology Programme (CNIO)
- Giovanna Roncador
- Monoclonal Antibodies Unit, Biotechnology Programme (CNIO)
- Juan C. de Agustín Asensio
- Department of Pediatric Surgery, Hospital Gregorio Marañón
- Colin R. Goding
- Nuffield Department of Medicine, Institute for Cancer Research, University of Oxford
- Eduardo Eyras
- Department of Experimental and Health Sciences, Universidad Pompeu Fabra
- Diego Megías
- Confocal Microscopy Unit, (CNIO)
- Raúl Méndez
- Institució Catalana de Recerca i Estudis Avançats (ICREA)
- María S. Soengas
- Melanoma Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
- DOI
- https://doi.org/10.1038/ncomms13418
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 17
Abstract
Cytoplasmic polyadenylated transcripts have been poorly characterized, particularly in cancer. Here the authors identify a lineage-specific requirement of the cytoplasmic polyadenylation binding protein 4 (CPEB4) in malignant melanoma and show that it controls melanoma drivers MITF and RAB27A.
