Constituents of the Stem Bark of <i>Symphonia globulifera</i> Linn. f. with Antileishmanial and Antibacterial Activities
Ruland Tchuinkeu Nguengang,
Billy Toussie Tchegnitegni,
Eric Carly Nono Nono,
Georges Bellier Tabekoueng,
Yannick Stéphane Fotsing Fongang,
Jean Jules Kezetas Bankeu,
Jean Rodolphe Chouna,
Céline Nguefeu Nkenfou,
Fabrice Boyom Fekam,
Norbert Sewald,
Bruno Ndjakou Lenta
Affiliations
Ruland Tchuinkeu Nguengang
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé P.O. Box 812, Cameroon
Billy Toussie Tchegnitegni
Department of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon
Eric Carly Nono Nono
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé P.O. Box 812, Cameroon
Georges Bellier Tabekoueng
Department of Chemistry, Faculty of Science, University of Douala, Douala P.O. Box 24157, Cameroon
Yannick Stéphane Fotsing Fongang
Department of Chemistry, Higher Teachers’ Training College, The University of Maroua, Maroua P.O. Box 55, Cameroon
Jean Jules Kezetas Bankeu
Department of Chemistry, Faculty of Science, The University of Bamenda, Bambili P.O. Box 39, Cameroon
Jean Rodolphe Chouna
Department of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon
Céline Nguefeu Nkenfou
Department of Biology, Higher Teacher Training College, University of Yaoundé I, Yaoundé P.O. Box 47, Cameroon
Fabrice Boyom Fekam
Antimicrobial & Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, University of Yaoundé I, Yaoundé P.O. Box 812, Cameroon
Norbert Sewald
Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany
Bruno Ndjakou Lenta
Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé P.O. Box 47, Cameroon
The chemical investigation of the n-hexane fraction from the methanol extract of the stem bark of Symphonia globulifera Linn f., which displayed good in vitro activity against Leishmania donovani NR-48822 promastigotes (IC50 43.11 µg/mL), led to the isolation of three previously unreported polyprenylated benzophenones, guttiferone U (1), V (2)/W (3), and a new tocotrienol derivative named globuliferanol (4), along with 11 known compounds (5–15). Their structures were elucidated based on their NMR and MS data. Some isolated compounds were assessed for both their antileishmanial and cytotoxic activities against L. donovani and Vero cells, respectively. Guttiferone K (5) exhibited the best potency (IC50 3.30 μg/mL), but with low selectivity to Vero cells. The n-hexane fraction and some compounds were also assessed in vitro for their antibacterial activity against seven bacterial strains. All the samples exhibited moderate to potent antibacterial activity (MICs ≤ 15.6 µg/mL) against at least one of the tested strains.
