Applications of platelet rich fibrin in dentistry

Abstract

Platelet-rich fibrin (PRF), a second-generation platelet concentrate, comprises a fibrin matrix containing numerous growth factors. These growth factors are involved with the cells responsible for the processes of tissue repair, regeneration, and growth. The applications of PRF have surpassed those of other platelet concentrates such as platelet-rich plasma due to the ease and economical method of its preparation, as well the elimination of the need for supplemental exogenous compounds like bovine thrombin and calcium chloride during preparation. This brief communication highlights the applications of PRF in dentistry and medicine and focuses on its preparation method, as it involves low risks and satisfactory results with minimally invasive techniques.

Keywords

• platelet
• growth factors
• periodontal regeneration
• guided bone regeneration
• soft tissue root coverage