Nanotechnology Reviews (Jun 2022)

Synthesis and application of nanometer hydroxyapatite in biomedicine

  • Gui Xingyu,
  • Peng Wei,
  • Xu Xiujuan,
  • Su Zixuan,
  • Liu Gang,
  • Zhou Zhigang,
  • Liu Ming,
  • Li Zhao,
  • Song Geyang,
  • Zhou Changchun,
  • Kong Qingquan

Journal volume & issue
Vol. 11, no. 1
pp. 2154 – 2168


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Nano-hydroxyapatite (nano-HA) has been widely studied as a promising biomaterial because of its potential mechanical and biological properties. In this article, different synthesis methods for nano-HA were summarized. Key factors for the synthesis of nano-HA, including reactant concentration, effects of temperature, PH, additives, aging time, and sintering, were separately investigated. The biological performances of the nano-HA depend strongly on its structures, morphology, and crystallite sizes. Nano-HA with different morphologies may cause different biological effects, such as protein adsorption, cell viability and proliferation, angiogenesis, and vascularization. Recent research progress with respect to the biological functions of the nano-HA in some specific biological applications are summarized and the future development of nano-sized hydroxyapatite is prospected.