Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Abstract

Highlights Stimuli-responsive gene delivery nanocarriers (GDNCs) possess huge potential in the gene therapy field owing to their effective protection, prolonged blood circulation, selective and targeted delivery, and controlled release of nucleic acid drugs. Recent advances in stimuli-responsive GDNCs for cancer therapy are classified, summarized, and exhibited by representative examples. The potential challenges and prospects of stimuli-responsive GDNCs toward clinical translation are outlined and the future research directions are outlooked.

Keywords

• Stimuli-responsive
• Nanocarrier
• Gene therapy
• Gene delivery
• Cancer