Frontiers in Pharmacology (Jun 2022)

Therapeutic Potential of Triptolide in Treating Bone-Related Disorders

  • Wu Gang,
  • Wu Gang,
  • Wu Gang,
  • Hu Hao,
  • Hu Hao,
  • Hu Hao,
  • Huang Yong,
  • Huang Yong,
  • Huang Yong,
  • Feng Ruibing,
  • Feng Ruibing,
  • Feng Ruibing,
  • Li Chaowen,
  • Huang Yizheng,
  • Huang Yizheng,
  • Huang Yizheng,
  • Li Chao,
  • Li Chao,
  • Li Chao,
  • Zhang Haitao,
  • Zhang Haitao,
  • Zhang Haitao

DOI
https://doi.org/10.3389/fphar.2022.905576
Journal volume & issue
Vol. 13

Abstract

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Triptolide, a diterpene triepoxide, is a pharmacologically active compound isolated from a Chinese medicinal herb Tripterygium wilfordii Hook F (TwHF). Triptolide has attracted considerable attention in recent times due to its multiple biological and pharmaceutical activities, with an emphasis on therapeutic importance in the treatment of diverse disorders. With essential medicinal implications, TwHF’s extracts have been used as anti-inflammatory, antiproliferative, antioxidative, and immunosuppressive agents for centuries, with continuous and relevant modifications to date to enhance its utility in several diseases and pathophysiology. Here, in this review, we accentuate the studies, highlighting the effects of triptolide on treating bone-related disorders, both inflammatory and cancerous, particularly osteosarcoma, and their manifestations. Based on this review, future avenues could be estimated for potential research strategies, molecular mechanisms, and outcomes that might contribute toward reinforcing new dimensions in the clinical application of triptolide in treating bone-related disorders.

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