Nature Communications (Jun 2022)
High throughput, label-free isolation of circulating tumor cell clusters in meshed microwells
- Mert Boya,
- Tevhide Ozkaya-Ahmadov,
- Brandi E. Swain,
- Chia-Heng Chu,
- Norh Asmare,
- Ozgun Civelekoglu,
- Ruxiu Liu,
- Dohwan Lee,
- Sherry Tobia,
- Shweta Biliya,
- L. DeEtte McDonald,
- Bassel Nazha,
- Omer Kucuk,
- Martin G. Sanda,
- Benedict B. Benigno,
- Carlos S. Moreno,
- Mehmet A. Bilen,
- John F. McDonald,
- A. Fatih Sarioglu
Affiliations
- Mert Boya
- School of Electrical and Computer Engineering, Georgia Institute of Technology
- Tevhide Ozkaya-Ahmadov
- School of Electrical and Computer Engineering, Georgia Institute of Technology
- Brandi E. Swain
- School of Electrical and Computer Engineering, Georgia Institute of Technology
- Chia-Heng Chu
- School of Electrical and Computer Engineering, Georgia Institute of Technology
- Norh Asmare
- School of Electrical and Computer Engineering, Georgia Institute of Technology
- Ozgun Civelekoglu
- School of Electrical and Computer Engineering, Georgia Institute of Technology
- Ruxiu Liu
- School of Electrical and Computer Engineering, Georgia Institute of Technology
- Dohwan Lee
- School of Electrical and Computer Engineering, Georgia Institute of Technology
- Sherry Tobia
- University Gynecologic Oncology
- Shweta Biliya
- Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
- L. DeEtte McDonald
- Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
- Bassel Nazha
- Winship Cancer Institute, Emory University
- Omer Kucuk
- Winship Cancer Institute, Emory University
- Martin G. Sanda
- Department of Urology, Emory University School of Medicine
- Benedict B. Benigno
- Integrated Cancer Research Center, Georgia Institute of Technology
- Carlos S. Moreno
- Winship Cancer Institute, Emory University
- Mehmet A. Bilen
- Winship Cancer Institute, Emory University
- John F. McDonald
- Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
- A. Fatih Sarioglu
- School of Electrical and Computer Engineering, Georgia Institute of Technology
- DOI
- https://doi.org/10.1038/s41467-022-31009-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Metastatic CTC clusters remain relatively unexplored due to the lack of optimized and practical technologies for their detection. Here the authors report Cluster-Wells to isolate CTC clusters in whole blood; they show this allows viable cluster retrieval for further molecular and functional analysis.
