Associations of blood pressure in the third trimester and risk of venous thromboembolism postpartum
Qian Li,
Hongfei Wang,
Huafang Wang,
Jun Deng,
Zhipeng Cheng,
Fengjuan Fan,
Wenyi Lin,
Ruiqi Zhu,
Shi Chen,
Jinrong Guo,
Yuxiong Weng,
Liang V. Tang,
Yu Hu
Affiliations
Qian Li
Institute of Hematology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
Hongfei Wang
Department of Cardiovascular Surgery Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
Huafang Wang
Institute of Hematology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
Jun Deng
Institute of Hematology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
Zhipeng Cheng
Institute of Hematology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
Fengjuan Fan
Institute of Hematology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
Wenyi Lin
Institute of Hematology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
Ruiqi Zhu
Institute of Hematology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
Shi Chen
Department of Biobank Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
Jinrong Guo
Department of Medical Records Management and Statistics Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
Yuxiong Weng
Department of Hand Surgery Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
Liang V. Tang
Institute of Hematology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
Yu Hu
Institute of Hematology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
Abstract Studies on the associations of blood pressure (BP) and the risk of venous thromboembolism (VTE) had been performed neither among pregnant women nor in Chinese population. This study included participants of pregnant women from a retrospective multicenter cohort, between May 2020 and April 2023. Systolic BP (SBP) and diastolic BP (DBP) of the participants were measured in the third trimester. The incidences of VTE (including deep venous thrombosis and/or pulmonary embolism) at 42 days postpartum were followed. With regards to SBP, pregnant women in the Q1 (≤114 mmHg), Q2 (115–122 mmHg), and Q4 group (≥131 mmHg) had increased risk of VTE than those in Q3 group (123–130 mmHg), with ORs 4.48 [1.69, 11.85], 3.52 [1.30, 9.59], and 3.17 [1.12, 8.99], respectively. Compared with pregnant women with the Q4 of DBP (≥85 mmHg), women of Q1 (≤71 mmHg) were found to have elevated risk of VTE (OR 2.73 [1.25, 5.96]). A one standard deviation decrease of DBP (9 mmHg) was related with 37% elevated risk of VTE (OR 1.37 [1.05, 1.79]). This study demonstrated a U‐shaped association of SBP in the third trimester and VTE postpartum and inverse association of DBP in the third trimester and VTE postpartum.
