Chloral Hydrate Alters Brain Activation Induced by Methamphetamine-Associated Cue and Prevents Relapse

Chenyu Jiang; Chenyu Jiang; Yunlong Xu; Yunlong Xu; Jiafeng Zhong; Jiafeng Zhong; Junyan Wu; Junyan Wu; Junyan Wu; Jian He; Jian He; Wei Xu; Wei Xu; Yingjie Zhu; Yingjie Zhu; Yingjie Zhu; Yingjie Zhu; Yingjie Zhu

doi:10.3389/fnmol.2022.934167

Frontiers in Molecular Neuroscience (Jul 2022)

Chloral Hydrate Alters Brain Activation Induced by Methamphetamine-Associated Cue and Prevents Relapse

Chenyu Jiang,
Chenyu Jiang,
Yunlong Xu,
Yunlong Xu,
Jiafeng Zhong,
Jiafeng Zhong,
Junyan Wu,
Junyan Wu,
Junyan Wu,
Jian He,
Jian He,
Wei Xu,
Wei Xu,
Yingjie Zhu,
Yingjie Zhu,
Yingjie Zhu,
Yingjie Zhu,
Yingjie Zhu

Affiliations

Chenyu Jiang: Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Chinese Academy of Sciences, Shenzhen, China
Chenyu Jiang: College of Life Science, University of Chinese Academy of Sciences, Beijing, China
Yunlong Xu: Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Chinese Academy of Sciences, Shenzhen, China
Yunlong Xu: College of Life Science, University of Chinese Academy of Sciences, Beijing, China
Jiafeng Zhong: Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Chinese Academy of Sciences, Shenzhen, China
Jiafeng Zhong: College of Life Science, University of Chinese Academy of Sciences, Beijing, China
Junyan Wu: Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Chinese Academy of Sciences, Shenzhen, China
Junyan Wu: The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Junyan Wu: Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China
Jian He: Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Chinese Academy of Sciences, Shenzhen, China
Jian He: Department of Anesthesiology, The First People’s Hospital of Foshan, Foshan, China
Wei Xu: Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Chinese Academy of Sciences, Shenzhen, China
Wei Xu: College of Life Science, University of Chinese Academy of Sciences, Beijing, China
Yingjie Zhu: Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Chinese Academy of Sciences, Shenzhen, China
Yingjie Zhu: College of Life Science, University of Chinese Academy of Sciences, Beijing, China
Yingjie Zhu: Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Yingjie Zhu: CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China
Yingjie Zhu: CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China

DOI: https://doi.org/10.3389/fnmol.2022.934167
Journal volume & issue: Vol. 15

Abstract

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Methamphetamine is a highly addictive drug and its abuse leads to serious health and social problems. Until now, no effective medications are yet available for the treatment of methamphetamine addiction. Our study reveals that chloral hydrate, a clinical sedative drug, suppresses the seeking desire for methamphetamine. After 5 days of continuous administration (subanesthetic dose 50 mg/kg and 100 mg/kg), methamphetamine-seeking behavior of rats was inhibited in the condition place preference and intravenous self-administration tests. Furthermore, chloral hydrate treatment robustly suppressed cue-induced methamphetamine relapse. The whole brain c-fos immunostaining revealed that chloral hydrate treatment suppressed neuronal activity in the rhomboid thalamic nucleus (Rh), dorsal endopiriform nucleus (dEn), and claustrum (Cl) while enhanced zona incerta (ZI) activity during cue-induced methamphetamine relapse. Therefore, chloral hydrate could remodel neural network activity and serve as a potential medicine to treat methamphetamine addiction.

Published in Frontiers in Molecular Neuroscience

ISSN: 1662-5099 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/molecular-neuroscience

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