Molecular perspective and anticancer activity of medicinal plants

Anis Ahamed; A. Panneerselvam; Abdullah Alaklabi; Ibrahim A. Arif; V. Ambikapathy; N. Thajuddin

Saudi Journal of Biological Sciences (Feb 2020)

Molecular perspective and anticancer activity of medicinal plants

Anis Ahamed,
A. Panneerselvam,
Abdullah Alaklabi,
Ibrahim A. Arif,
V. Ambikapathy,
N. Thajuddin

Affiliations

Anis Ahamed: Prince Sultan Research Chair for Environment and Wildlife, Department of Botany and Microbiology, College of Sciences, King Saud University (KSU), Riyadh, Saudi Arabia; Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi, Affiliated to Bharathidasan University, Thanjavur, India; Corresponding author.
A. Panneerselvam: Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi, Affiliated to Bharathidasan University, Thanjavur, India
Abdullah Alaklabi: Faculty of Science, Department of Biological Science, University of Jeddah, Jeddah, Saudi Arabia
Ibrahim A. Arif: Prince Sultan Research Chair for Environment and Wildlife, Department of Botany and Microbiology, College of Sciences, King Saud University (KSU), Riyadh, Saudi Arabia
V. Ambikapathy: Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi, Affiliated to Bharathidasan University, Thanjavur, India
N. Thajuddin: Department of Microbiology, Bharathidasan University, Tiruchirappalli, India

Journal volume & issue: Vol. 27, no. 2
pp. 666 – 675

Abstract

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To evaluate phytochemical constituents from the methanolic extracts of medicinal plants Aloe castellorum and Aloe pseudorubroviolacea. The cytotoxic activity of Aloe castellorum and Aloe pseudorubroviolacea leaf extracts against Human colon cancer cell line (HCT-116) was also assessed. The two medicinal plant extracts having significant cytotoxic activity, meanwhile the methanolic extract of Aloe castellorum shows higher cytotoxic activity than Aloe pseudorubroviolacea extract. The Aloe castellorum shows remarkable activity against respective cell line than control. The characteristic chemical constituents of Aloe castellorum and Aloe pseudorubroviolacea leaf extracts were recognized from Gas chromatography and Mass spectrometry (GC–MS) technique. The molecular docking studies also support the cytotoxic activity. Keywords: Aloe castellorum, Aloe pseudorubroviolacea, Anticancer activity, Molecular docking

Published in Saudi Journal of Biological Sciences

ISSN: 1319-562X (Print)
Publisher: Elsevier
Country of publisher: Saudi Arabia
LCC subjects: Science: Biology (General)
Website: http://www.journals.elsevier.com/saudi-journal-of-biological-sciences/

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