Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion

Abstract

Effective delivery of signals from the cell surface to the nucleus is a key to activate gene transcription. Here, the authors show how endosomes containing EphA2 are transported and captured at the nuclear surface, triggering depletion of G-actin from the nucleus and activating MRTF signalling.