Early Exercise Training After Renal Transplantation and Asymmetric Dimethylarginine: The Effect of Obesity

Abstract

Background/Aims: To assess, in a prospective cohort study of 238 renal transplant patients, our hypothesis that elevated ADMA levels may be influenced by physical exercise and obesity. Methods: Blood samples before and after six months were obtained from 116 transplant patients participating in an aerobic exercise (Group I). A control group consisted of 122 matched transplant patients who did not exercise regularly (Group II). Results: There were no significant differences in ADMA levels between both groups before the training program (Group IB vs Group IIB). After six months of exercise, ADMA levels in Group I decreased (Group IB vs Group IA : 3.50 ± 0.45 vs 2.11 ± 0.35μmol/L; pA vs Group IIA : 2 11 ± 0 23 vs 3 25 ± 0 34μmol/L; p2) confirmed a smaller effect of exercise training (Group IBO vs Group IAO : 3 75 ± 0 52 vs 3 45 ± 0 45; pAO vs Group IIAO : 3.45 ± 0.45 vs 3.74 ± 0.62; p1C, insulin, and systolic BP were also affected by the training program. Conclusion: Elevated ADMA levels were significantly decreased by early exercise after renal transplantation. The effect of exercise was smaller in obese patients.

Keywords

• Physical Exercise
• Renal Transplantation
• ADMA
• Obesity