Nickel-catalyzed esterification of mandelic acids with alcohols

Changhong Liu; Mamat Marhaba; Abdukerem Dilshat; Wenli Zhu; Kun Xia; Zechuan Mao; Abdukader Ablimit

Arabian Journal of Chemistry (Jan 2023)

Nickel-catalyzed esterification of mandelic acids with alcohols

Changhong Liu,
Mamat Marhaba,
Abdukerem Dilshat,
Wenli Zhu,
Kun Xia,
Zechuan Mao,
Abdukader Ablimit

Affiliations

Changhong Liu: State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources; College of Chemistry, Xinjiang University, Urumqi 830017, Xinjiang, PR China
Mamat Marhaba: State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources; College of Chemistry, Xinjiang University, Urumqi 830017, Xinjiang, PR China
Abdukerem Dilshat: State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources; College of Chemistry, Xinjiang University, Urumqi 830017, Xinjiang, PR China
Wenli Zhu: State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources; College of Chemistry, Xinjiang University, Urumqi 830017, Xinjiang, PR China
Kun Xia: State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources; College of Chemistry, Xinjiang University, Urumqi 830017, Xinjiang, PR China
Zechuan Mao: State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources; College of Chemistry, Xinjiang University, Urumqi 830017, Xinjiang, PR China
Abdukader Ablimit: Corresponding author.; State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources; College of Chemistry, Xinjiang University, Urumqi 830017, Xinjiang, PR China

Journal volume & issue: Vol. 16, no. 1
p. 104407

Abstract

Read online

Mandelates and their derivatives are widely used in organic synthesis, drug discovery, biodegradable polymers and other related fields. Therefore, the effective and simple synthesis of these compounds has attracted much attention. In this paper, a nickel(II)-catalyzed esterification of mandelic acids with different alcohols was realized for the synthesis of mandelic acid esters. This transformation was conducted under mild reaction conditions with yields up to 95%, and was successfully utilized in the gram-scale synthesis of medicine cyclandelate.

Published in Arabian Journal of Chemistry

ISSN: 1878-5352 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/arabian-journal-of-chemistry/

About the journal

Abstract

Keywords