ALDOSTERONE LEVELS AND HEART REMODELING IN MYOCARDIAL INFARCTION PATIENTS WITH NON-DIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

Abstract

Aim. To assess the dynamics of aldosterone in blood serum and structurefunctional parameters of the heart in myocardial infarction patients, developed on the background of non-differentiated connective tissue dysplasia.Material and methods. Totally, 90 patients included with Q-myocardial infarction with non-differentiated connective tissue dysplasia and without it. The controls were almost healthy persons without cardiovascular pathology, comparison group — patients with connective tissue dysplasia but not having cardiovascular pathology. Clinical and phenotypic assessment was done, echocardiography, aldosterone levels measurement in serum at dynamics of the infarction course.Results. All patients, independent of existence of connective tissue dysplasia, showed aldosterone elevation at 1st day of infarction with further decrease to the level of controls or comparison in 28 days. In the group of infarction patients with non-differentiated connective tissue dysplasia there was significant enlargement of the left ventricle size, reduced pumping function with tendency to less prominent myocardial mass index increase comparing with those not having dysplasia.Conclusion. Presence of non-differentiated connective tissue dysplasia does not influence aldosterone levels and their dynamics in myocardial infarction, but is associated with adverse type of postinfarction remodeling of the heart presenting with the left ventricle dilatation and decrease of its pumping function.

Keywords

• myocardial infarction
• undifferentiated connective tissue dysplasia
• aldosterone
• postinfarction remodeling of heart