Cell type-specific induction of ferroptosis to boost antitumor immunity

Abstract

ABSTRACTTraditional ferroptosis activators typically suppress antitumor immunity. Our discovery shows that N6F11, a small molecule compound, can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. This breakthrough establishes a safe and effective strategy to enhance ferroptosis-driven antitumor immunity.

Keywords

• Drug discovery
• ferroptosis
• GPX4
• immunotherapy
• TRIM25