Frontiers in Immunology (Apr 2021)
How to Manage COVID-19 Vaccination in Immune-Mediated Inflammatory Diseases: An Expert Opinion by IMIDs Study Group
- Francesca Ferretti,
- Rosanna Cannatelli,
- Maurizio Benucci,
- Stefania Carmagnola,
- Emilio Clementi,
- Emilio Clementi,
- Piergiorgio Danelli,
- Dario Dilillo,
- Paolo Fiorina,
- Paolo Fiorina,
- Paolo Fiorina,
- Massimo Galli,
- Maurizio Gallieni,
- Maurizio Gallieni,
- Giovanni Genovese,
- Giovanni Genovese,
- Valeria Giorgi,
- Alessandro Invernizzi,
- Alessandro Invernizzi,
- Giovanni Maconi,
- Jeanette A. Maier,
- Angelo V. Marzano,
- Angelo V. Marzano,
- Paola S. Morpurgo,
- Manuela Nebuloni,
- Dejan Radovanovic,
- Agostino Riva,
- Giuliano Rizzardini,
- Giuliano Rizzardini,
- Gianmarco Sabiu,
- Gianmarco Sabiu,
- Pierachille Santus,
- Pierachille Santus,
- Giovanni Staurenghi,
- Gianvincenzo Zuccotti,
- Pier Carlo Sarzi-Puttini,
- Sandro Ardizzone
Affiliations
- Francesca Ferretti
- Gastroenterology Unit, ASST Fatebenefratelli-Sacco, Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Rosanna Cannatelli
- Gastroenterology Unit, ASST Fatebenefratelli-Sacco, Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Maurizio Benucci
- Rheumatology Unit, S. Giovanni di Dio Hospital, Azienda USL-Toscana Centro, Florence, Italy
- Stefania Carmagnola
- Gastroenterology Unit, ASST Fatebenefratelli-Sacco, Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Emilio Clementi
- Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Emilio Clementi
- Scientific Institute IRCCS E. Medea, Lecco, Italy
- Piergiorgio Danelli
- Surgery Unit, ASST Fatebenefratelli Sacco, Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Dario Dilillo
- Pediatric Department, Ospedale dei Bambini, ASST Fatebenefratelli Sacco, Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Paolo Fiorina
- Division of Endocrinology, ASST Fatebenefratelli - Sacco, Milan, Italy
- Paolo Fiorina
- International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università Degli Studi di Milano, Milan, Italy
- Paolo Fiorina
- Nephrology Division, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States
- Massimo Galli
- 0Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, III Infectious Diseases unit, University Hospital “Luigi Sacco”, Milan, Italy
- Maurizio Gallieni
- 1Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Maurizio Gallieni
- 2Nephrology and Dialysis Unit, “L. Sacco” Hospital, ASST Fatebenefratelli-Sacco, Milano, Italy
- Giovanni Genovese
- 3Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
- Giovanni Genovese
- 4Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy
- Valeria Giorgi
- 5Rheumatology Unit, Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Alessandro Invernizzi
- 6Eye Clinic, Department of Biomedical and Clinical Sciences Luigi Sacco, Università degli Studi di Milano, Milan, Italy
- Alessandro Invernizzi
- 7The University of Sydney, Save Sight Institute, Discipline of Ophthalmology, Sydney Medical School, Sydney, NSW, Australia
- Giovanni Maconi
- Gastroenterology Unit, ASST Fatebenefratelli-Sacco, Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Jeanette A. Maier
- 1Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Angelo V. Marzano
- 3Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
- Angelo V. Marzano
- 4Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy
- Paola S. Morpurgo
- Division of Endocrinology, ASST Fatebenefratelli - Sacco, Milan, Italy
- Manuela Nebuloni
- 8Pathology Unit, Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Dejan Radovanovic
- 9Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Milan, Italy
- Agostino Riva
- 1Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Giuliano Rizzardini
- 0Department of Infectious Diseases, ASST Fatebenefratelli-Sacco, Università degli Studi di Milano, Milan, Italy
- Giuliano Rizzardini
- 1School of Clinical Medicine, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa
- Gianmarco Sabiu
- 1Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Gianmarco Sabiu
- 2Nephrology and Dialysis Unit, “L. Sacco” Hospital, ASST Fatebenefratelli-Sacco, Milano, Italy
- Pierachille Santus
- 1Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Pierachille Santus
- 9Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Milan, Italy
- Giovanni Staurenghi
- 6Eye Clinic, Department of Biomedical and Clinical Sciences Luigi Sacco, Università degli Studi di Milano, Milan, Italy
- Gianvincenzo Zuccotti
- Pediatric Department, Ospedale dei Bambini, ASST Fatebenefratelli Sacco, Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Pier Carlo Sarzi-Puttini
- 5Rheumatology Unit, Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- Sandro Ardizzone
- Gastroenterology Unit, ASST Fatebenefratelli-Sacco, Department of Biomedical and Clinical Sciences (DIBIC) L. Sacco, Università degli Studi di Milano, Milan, Italy
- DOI
- https://doi.org/10.3389/fimmu.2021.656362
- Journal volume & issue
-
Vol. 12
Abstract
Since March 2020, the outbreak of Sars-CoV-2 pandemic has changed medical practice and daily routine around the world. Huge efforts from pharmacological industries have led to the development of COVID-19 vaccines. In particular two mRNA vaccines, namely the BNT162b2 (Pfizer-BioNTech) and the mRNA-1273 (Moderna), and a viral-vectored vaccine, i.e. ChAdOx1 nCoV-19 (AstraZeneca), have recently been approved in Europe. Clinical trials on these vaccines have been published on the general population showing a high efficacy with minor adverse events. However, specific data about the efficacy and safety of these vaccines in patients with immune-mediated inflammatory diseases (IMIDs) are still lacking. Moreover, the limited availability of these vaccines requires prioritizing some vulnerable categories of patients compared to others. In this position paper, we propose the point of view about the management of COVID-19 vaccination from Italian experts on IMIDs and the identification of high-risk groups according to the different diseases and their chronic therapy.
Keywords
