The role of oleuropein against nanocomposite toxicity in fruit fly: evidence for lifespan extension

Abstract

The effect of zinc oxide/titanium dioxide nanocomposite the lifespan of the fruit fly Drosophila melanogaster and the protective role of oleuropein, a strong antioxidant, against the zinc oxide/titanium dioxide were investigated. Chemicals prepared in different concentrations (0.005, 0.1, 0.5, and 1 g/L for zinc oxide/titanium dioxide; 0.1 mmol/L for oleuropein) have been separately applied to female and male populations of D. melanogaster for the control and application groups. In both female and male populations, it has been observed that zinc oxide/titanium dioxide has decreased the lifespan and oleuropein has increased the lifespan according to the control group, depending on the concentration. These findings demonstrate the beneficial effect of oleuropein, suggested as a protective role in the prevention of zinc oxide/titanium dioxide induced developmental toxicity.

Keywords

• Drosophila melanogaster
• lifespan
• oleuropein
• toxicity
• zinc oxide/titanium dioxide nanoparticles