Effects of Probiotics and Gut Microbiota on Bone Metabolism in Chickens: A Review
Pan Chen,
Tingting Xu,
Chaodong Zhang,
Xishuai Tong,
Aftab Shaukat,
Yanfeng He,
Kaili Liu,
Shucheng Huang
Affiliations
Pan Chen
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
Tingting Xu
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
Chaodong Zhang
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
Xishuai Tong
Institutes of Agricultural Science and Technology Development (Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China)/College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
Aftab Shaukat
National Center for International Research on Animal Genetics, Breeding and Reproduction (NCIRAGBR), Huazhong Agricultural University, Wuhan 430070, China
Yanfeng He
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
Kaili Liu
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
Shucheng Huang
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
Broiler leg diseases are a common abnormal bone metabolism issue that leads to poor leg health in growing poultry. Bone metabolism is a complicated regulatory process controlled by genetic, nutritional, feeding management, environmental, or other influencing factors. The gut microbiota constitutes the largest micro-ecosystem in animals and is closely related to many metabolic disorders, including bone disease, by affecting the absorption of nutrients and the barrier function of the gastrointestinal tract and regulating the immune system and even the brain–gut–bone axis. Recently, probiotic-based dietary supplementation has emerged as an emerging strategy to improve bone health in chickens by regulating bone metabolism based on the gut–bone axis. This review aims to summarize the regulatory mechanisms of probiotics in the gut microbiota on bone metabolism and to provide new insights for the prevention and treatment of bone diseases in broiler chickens.