Redox Imbalances in Ageing and Metabolic Alterations: Implications in Cancer and Cardiac Diseases. An Overview from the Working Group of Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology (SIC)
Valentina Mercurio,
Alessandra Cuomo,
Christian Cadeddu Dessalvi,
Martino Deidda,
Daniela Di Lisi,
Giuseppina Novo,
Roberta Manganaro,
Concetta Zito,
Ciro Santoro,
Pietro Ameri,
Paolo Spallarossa,
Eleonora Arboscello,
Carlo Gabriele Tocchetti,
Claudia Penna
Affiliations
Valentina Mercurio
Department of Translational Medical Sciences, Federico II University, 80131 Naples, Italy
Alessandra Cuomo
Department of Translational Medical Sciences, Federico II University, 80131 Naples, Italy
Christian Cadeddu Dessalvi
Department of Medical Sciences and Public Health, University of Cagliari, 09042 Cagliari, Italy
Martino Deidda
Department of Medical Sciences and Public Health, University of Cagliari, 09042 Cagliari, Italy
Daniela Di Lisi
Cardiology Unit AUOP Policlinico, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy
Giuseppina Novo
Cardiology Unit AUOP Policlinico, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy
Roberta Manganaro
Cardiology with Coronary Intensive Care Unit, Department of Clinical and Experimental Medicine, University Hospital Policlinico “G. Martino”, University of Messina, 98124 Messina, Italy
Concetta Zito
Cardiology with Coronary Intensive Care Unit, Department of Clinical and Experimental Medicine, University Hospital Policlinico “G. Martino”, University of Messina, 98124 Messina, Italy
Ciro Santoro
Department of Advanced Biomedical Sciences, Federico II University, 80131 Naples, Italy
Pietro Ameri
Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy—IRCCS Italian Cardiovascular Network & Department of Internal Medicine, University of Genova, 16121 Genova, Italy
Paolo Spallarossa
Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy—IRCCS Italian Cardiovascular Network & Department of Internal Medicine, University of Genova, 16121 Genova, Italy
Eleonora Arboscello
Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy—IRCCS Italian Cardiovascular Network & Department of Internal Medicine, University of Genova, 16121 Genova, Italy
Carlo Gabriele Tocchetti
Department of Translational Medical Sciences, Federico II University, 80131 Naples, Italy
Claudia Penna
Department of Clinical and Biological Sciences, University of Turin, 10043 Torino, Italy
Metabolic syndrome (MetS) is a well established risk factor for cardiovascular (CV) diseases. In addition, several studies indicate that MetS correlates with the increased risk of cancer in adults. The mechanisms linking MetS and cancer are not fully understood. Several risk factors involved in MetS are also cancer risk factors, such as the consumption of high calorie-food or high fat intake, low fibre intake, and sedentary lifestyle. Other common aspects of both cancer and MetS are oxidative stress and inflammation. In addition, some anticancer treatments can induce cardiotoxicity, including, for instance, left ventricular (LV) dysfunction and heart failure (HF), endothelial dysfunction and hypertension. In this review, we analyse several aspects of MetS, cancer and cardiotoxicity from anticancer drugs. In particular, we focus on oxidative stress in ageing, cancer and CV diseases, and we analyse the connections among CV risk factors, cancer and cardiotoxicity from anticancer drugs.
