Nature Communications (May 2018)
Postnatal DNA demethylation and its role in tissue maturation
- Yitzhak Reizel,
- Ofra Sabag,
- Yael Skversky,
- Adam Spiro,
- Benjamin Steinberg,
- Diana Bernstein,
- Amber Wang,
- Julia Kieckhaefer,
- Catherine Li,
- Eli Pikarsky,
- Rena Levin-Klein,
- Alon Goren,
- Klaus Rajewsky,
- Klaus H. Kaestner,
- Howard Cedar
Affiliations
- Yitzhak Reizel
- Department of Developmental Biology and Cancer Research, Hebrew University Medical School
- Ofra Sabag
- Department of Developmental Biology and Cancer Research, Hebrew University Medical School
- Yael Skversky
- Department of Developmental Biology and Cancer Research, Hebrew University Medical School
- Adam Spiro
- Department of Developmental Biology and Cancer Research, Hebrew University Medical School
- Benjamin Steinberg
- Department of Developmental Biology and Cancer Research, Hebrew University Medical School
- Diana Bernstein
- Department of Genetics and Institute for Diabetes Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, 12-126 Translational Research Center
- Amber Wang
- Department of Genetics and Institute for Diabetes Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, 12-126 Translational Research Center
- Julia Kieckhaefer
- Department of Genetics and Institute for Diabetes Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, 12-126 Translational Research Center
- Catherine Li
- Broad Technology Labs (BTL), The Broad Institute of Harvard and MIT
- Eli Pikarsky
- Department of Developmental Biology and Cancer Research, Hebrew University Medical School
- Rena Levin-Klein
- Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota
- Alon Goren
- Broad Technology Labs (BTL), The Broad Institute of Harvard and MIT
- Klaus Rajewsky
- Immune Regulation and Cancer Max-Delbrück-Centrum für, Molekulare Medizin (MDC)
- Klaus H. Kaestner
- Department of Genetics and Institute for Diabetes Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, 12-126 Translational Research Center
- Howard Cedar
- Department of Developmental Biology and Cancer Research, Hebrew University Medical School
- DOI
- https://doi.org/10.1038/s41467-018-04456-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Here the authors show that a large fraction of the tissue-specific methylation pattern is generated postnatally. These changes, which occur in response to hormone signaling, appear to play a major role in the regulation of gene expression and tissue maturation in the liver.
