New Furanocembranoids from <i>Briareum violaceum</i>
Pin-Chang Huang,
Wen-Sou Lin,
Bo-Rong Peng,
Yu-Chia Chang,
Lee-Shing Fang,
Guo-Qiang Li,
Tsong-Long Hwang,
Zhi-Hong Wen,
Ping-Jyun Sung
Affiliations
Pin-Chang Huang
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan
Wen-Sou Lin
Department of Neurology, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan
Bo-Rong Peng
Department of Planning and Research, National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan
Yu-Chia Chang
Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan
Lee-Shing Fang
Center for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 83347, Taiwan
Guo-Qiang Li
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266033, China
Tsong-Long Hwang
Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan
Zhi-Hong Wen
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
Ping-Jyun Sung
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan
Three new furanocembranoids—briaviodiol F (1) and briaviotriols A (2) and B (3)—along with a known analogue, briaviodiol A (4), were obtained from a cultured-type octocoral Briareum violaceum. The structures of cembranoids 1–3 were elucidated by using spectroscopic methods. In vitro study demonstrated that compounds 2 and 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW 264.7, a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides.
