EClinicalMedicine (Jun 2023)

Artificial intelligence-assisted ultrasound image analysis to discriminate early breast cancer in Chinese population: a retrospective, multicentre, cohort studyResearch in context

  • Jianwei Liao,
  • Yu Gui,
  • Zhilin Li,
  • Zijian Deng,
  • Xianfeng Han,
  • Huanhuan Tian,
  • Li Cai,
  • Xingyu Liu,
  • Chengyong Tang,
  • Jia Liu,
  • Ya Wei,
  • Lan Hu,
  • Fengling Niu,
  • Jing Liu,
  • Xi Yang,
  • Shichao Li,
  • Xiang Cui,
  • Xin Wu,
  • Qingqiu Chen,
  • Andi Wan,
  • Jun Jiang,
  • Yi Zhang,
  • Xiangdong Luo,
  • Peng Wang,
  • Zhigang Cai,
  • Li Chen

Journal volume & issue
Vol. 60
p. 102001

Abstract

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Summary: Background: Early diagnosis of breast cancer has always been a difficult clinical challenge. We developed a deep-learning model EDL-BC to discriminate early breast cancer with ultrasound (US) benign findings. This study aimed to investigate how the EDL-BC model could help radiologists improve the detection rate of early breast cancer while reducing misdiagnosis. Methods: In this retrospective, multicentre cohort study, we developed an ensemble deep learning model called EDL-BC based on deep convolutional neural networks. The EDL-BC model was trained and internally validated on B-mode and color Doppler US image of 7955 lesions from 6795 patients between January 1, 2015 and December 31, 2021 in the First Affiliated Hospital of Army Medical University (SW), Chongqing, China. The model was assessed by internal and external validations, and outperformed radiologists. The model performance was validated in two independent external validation cohorts included 448 lesions from 391 patients between January 1 to December 31, 2021 in the Tangshan People's Hospital (TS), Chongqing, China, and 245 lesions from 235 patients between January 1 to December 31, 2021 in the Dazu People's Hospital (DZ), Chongqing, China. All lesions in the training and total validation cohort were US benign findings during screening and biopsy-confirmed malignant, benign, and benign with 3-year follow-up records. Six radiologists performed the clinical diagnostic performance of EDL-BC, and six radiologists independently reviewed the retrospective datasets on a web-based rating platform. Findings: The area under the receiver operating characteristic curve (AUC) of the internal validation cohort and two independent external validation cohorts for EDL-BC was 0.950 (95% confidence interval [CI]: 0.909–0.969), 0.956 (95% [CI]: 0.939–0.971), and 0.907 (95% [CI]: 0.877–0.938), respectively. The sensitivity values were 94.4% (95% [CI]: 72.7%–99.9%), 100% (95% [CI]: 69.2%–100%), and 80% (95% [CI]: 28.4%–99.5%), respectively, at 0.76. The AUC for accurate diagnosis of EDL-BC (0.945 [95% [CI]: 0.933–0.965]) and radiologists with artificial intelligence (AI) assistance (0.899 [95% [CI]: 0.883–0.913]) was significantly higher than that of the radiologists without AI assistance (0.716 [95% [CI]: 0.693–0.738]; p < 0.0001). Furthermore, there were no significant differences between the EDL-BC model and radiologists with AI assistance (p = 0.099). Interpretation: EDL-BC can identify subtle but informative elements on US images of breast lesions and can significantly improve radiologists' diagnostic performance for identifying patients with early breast cancer and benefiting the clinical practice. Funding: The National Key R&D Program of China.

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