TITAN Project: Microfluidic and Sensing Tools for Immunotherapy
Maria Serena Chiriacò,
Elisabetta Primiceri,
Antonio Turco,
Valeria Garzarelli,
Giulia Siciliano,
Alessia Foscarini,
Ahmed Alsadig,
Annunziata Carbonara,
Benedetta Stampone,
Gianluca Trotta,
Marco Cereda,
Marco de Tullio,
Giuseppe Gigli,
Francesco Ferrara
Affiliations
Maria Serena Chiriacò
CNR NANOTEC—Institute of Nanotechnology, Via per Monteroni, 73100 Lecce, Italy
Elisabetta Primiceri
CNR NANOTEC—Institute of Nanotechnology, Via per Monteroni, 73100 Lecce, Italy
Antonio Turco
CNR NANOTEC—Institute of Nanotechnology, Via per Monteroni, 73100 Lecce, Italy
Valeria Garzarelli
CNR NANOTEC—Institute of Nanotechnology, Via per Monteroni, 73100 Lecce, Italy
Giulia Siciliano
CNR NANOTEC—Institute of Nanotechnology, Via per Monteroni, 73100 Lecce, Italy
Alessia Foscarini
CNR NANOTEC—Institute of Nanotechnology, Via per Monteroni, 73100 Lecce, Italy
Ahmed Alsadig
CNR NANOTEC—Institute of Nanotechnology, Via per Monteroni, 73100 Lecce, Italy
Annunziata Carbonara
Department of Mechanics, Mathematics and Management and Centre of Excellence for Computational Mechanics (CEMeC), Politecnico di Bari, 70125 Bari, Italy
Benedetta Stampone
Department of Mathematics & Physics E. de Giorgi, University of Salento, Via Arnesano, 73100 Lecce, Italy
Gianluca Trotta
CNR STIIMA—Institute of Intelligent Industrial Systems & Technologies, Via P Lembo 38-F, 70124 Bari, Italy
Marco Cereda
STMicroelectronics S.r.l., Via Olivetti 2, 20864 Agrate Brianza, Italy
Marco de Tullio
Department of Mechanics, Mathematics and Management and Centre of Excellence for Computational Mechanics (CEMeC), Politecnico di Bari, 70125 Bari, Italy
Giuseppe Gigli
CNR NANOTEC—Institute of Nanotechnology, Via per Monteroni, 73100 Lecce, Italy
Francesco Ferrara
CNR NANOTEC—Institute of Nanotechnology, Via per Monteroni, 73100 Lecce, Italy
The TITAN project aims to improve immunotherapy, targeting the efficiency of methods to obtain genetically engineered T cells. Immunotherapy has achieved great success in clinical trials, but it is currently very expensive in terms of time required for analysis, reagents, and samples. TITAN aims to the continuous sampling of critical quality attributes, in order to quickly recognize deviations from the desired range and take appropriate corrective actions on process parameters for an optimal outcome. To achieve its aims, TITAN is currently developing microfluidic and sensing tools for the accurate and efficient real-time monitoring of the T cells amplification process.
